GO Annotations Graph

• Symbol: Mkks
• Name: McKusick-Kaufman syndrome
• ID: MGI:1891836

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:73065
Molecular Function	GO:0051082	unfolded protein binding	IEA	J:72247
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0036064	ciliary basal body	IDA	J:184545
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:1902636	kinociliary basal body	IBA	J:265628
Cellular Component	GO:1902636	kinociliary basal body	IDA	J:184545
Cellular Component	GO:0031514	motile cilium	IMP	J:132765
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0014824	artery smooth muscle contraction	IMP	J:167249
Biological Process	GO:0048854	brain morphogenesis	IMP	J:128532
Biological Process	GO:0051216	cartilage development	IMP	J:194514
Biological Process	GO:0051216	cartilage development	IMP	J:194514
Biological Process	GO:0021987	cerebral cortex development	IMP	J:128532
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	IBA	J:265628
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	IMP	J:156536
Biological Process	GO:0060271	cilium assembly	ISO	J:164563
Biological Process	GO:0060271	cilium assembly	IMP	J:132765
Biological Process	GO:0060271	cilium assembly	IBA	J:265628
Biological Process	GO:0060271	cilium assembly	IMP	J:99276
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IMP	J:102697
Biological Process	GO:0032502	developmental process	IBA	J:265628
Biological Process	GO:0060324	face development	IMP	J:134638
Biological Process	GO:0045444	fat cell differentiation	IEP	J:135549
Biological Process	GO:0010467	gene expression	IMP	J:146158
Biological Process	GO:0010467	gene expression	IMP	J:146158
Biological Process	GO:0010467	gene expression	IMP	J:135832
Biological Process	GO:0021766	hippocampus development	IMP	J:128532
Biological Process	GO:0046907	intracellular transport	IBA	J:265628
Biological Process	GO:0033210	leptin-mediated signaling pathway	IMP	J:146158
Biological Process	GO:0030837	negative regulation of actin filament polymerization	IMP	J:201104
Biological Process	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	IMP	J:146158
Biological Process	GO:0045776	negative regulation of blood pressure	IMP	J:135832
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:135832
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:146158
Biological Process	GO:0034260	negative regulation of GTPase activity	IMP	J:201104
Biological Process	GO:1905515	non-motile cilium assembly	IMP	J:194514
Biological Process	GO:1905515	non-motile cilium assembly	IMP	J:102697
Biological Process	GO:1905515	non-motile cilium assembly	IGI	J:102697
Biological Process	GO:0045494	photoreceptor cell maintenance	IMP	J:99276
Biological Process	GO:0045494	photoreceptor cell maintenance	IMP	J:102697
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:135832
Biological Process	GO:0006457	protein folding	IEA	J:72247
Biological Process	GO:0060296	regulation of cilium beat frequency involved in ciliary motility	IMP	J:132765
Biological Process	GO:0051492	regulation of stress fiber assembly	IMP	J:201104
Biological Process	GO:0044321	response to leptin	IMP	J:135832
Biological Process	GO:0007608	sensory perception of smell	IMP	J:99276
Biological Process	GO:0007608	sensory perception of smell	IMP	J:102697
Biological Process	GO:0035176	social behavior	IMP	J:99276
Biological Process	GO:0007286	spermatid development	IMP	J:99276
Biological Process	GO:0021756	striatum development	IMP	J:128532
Biological Process	GO:0042311	vasodilation	IMP	J:167249