Trem2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Trem2
triggering receptor expressed on myeloid cells 2
MGI:1913150

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0034186	apolipoprotein A-I binding	ISO	J:164563
Molecular Function	GO:0034185	apolipoprotein binding	ISO	J:164563
Molecular Function	GO:0008035	high-density lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:210929
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:191922
Molecular Function	GO:0071813	lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0070891	lipoteichoic acid binding	IDA	J:210929
Molecular Function	GO:0030169	low-density lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0042834	peptidoglycan binding	IDA	J:210929
Molecular Function	GO:0008429	phosphatidylethanolamine binding	ISO	J:164563
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:277861
Molecular Function	GO:0005515	protein binding	IPI	J:183995
Molecular Function	GO:0005515	protein binding	IPI	J:191922
Molecular Function	GO:1990782	protein tyrosine kinase binding	IPI	J:260524
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	IMP	J:260524
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:164563
Molecular Function	GO:0120146	sulfatide binding	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISS	J:64954
Molecular Function	GO:0034189	very-low-density lipoprotein particle binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IMP	J:215678
Cellular Component	GO:0005886	plasma membrane	IDA	J:273534
Cellular Component	GO:0005886	plasma membrane	IMP	J:264653
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Biological Process	GO:0097242	amyloid-beta clearance	IMP	J:264653
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IMP	J:277170
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IMP	J:285719
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IMP	J:304709
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	ISO	J:164563
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:96626
Biological Process	GO:0048143	astrocyte activation	IGI	J:256924
Biological Process	GO:1904646	cellular response to amyloid-beta	IGI	J:260524
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0071396	cellular response to lipid	ISO	J:164563
Biological Process	GO:0071223	cellular response to lipoteichoic acid	IDA	J:210929
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0071224	cellular response to peptidoglycan	IDA	J:210929
Biological Process	GO:0150062	complement-mediated synapse pruning	IMP	J:273253
Biological Process	GO:0038160	CXCL12-activated CXCR4 signaling pathway	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IMP	J:266671
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:284724
Biological Process	GO:0097028	dendritic cell differentiation	ISO	J:164563
Biological Process	GO:0097062	dendritic spine maintenance	IMP	J:285719
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:210929
Biological Process	GO:0070392	detection of lipoteichoic acid	IDA	J:210929
Biological Process	GO:0032499	detection of peptidoglycan	IDA	J:210929
Biological Process	GO:1905805	excitatory synapse pruning	IMP	J:272738
Biological Process	GO:0098657	import into cell	IGI	J:256924
Biological Process	GO:0045087	innate immune response	IC	J:210929
Biological Process	GO:0055088	lipid homeostasis	IMP	J:283590
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IC	J:210929
Biological Process	GO:0007613	memory	ISO	J:164563
Biological Process	GO:0001774	microglial cell activation	IMP	J:242830
Biological Process	GO:0001774	microglial cell activation	IMP	J:273509
Biological Process	GO:0001774	microglial cell activation	IMP	J:304584
Biological Process	GO:0001774	microglial cell activation	IGI	J:256924
Biological Process	GO:0001774	microglial cell activation	IGI	J:260524
Biological Process	GO:0002282	microglial cell activation involved in immune response	IMP	J:266671
Biological Process	GO:0061518	microglial cell proliferation	IMP	J:274782
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	IMP	J:277170
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:273509
Biological Process	GO:0061889	negative regulation of astrocyte activation	IDA	J:305994
Biological Process	GO:1904093	negative regulation of autophagic cell death	IGI	J:242830
Biological Process	GO:0010507	negative regulation of autophagy	IMP	J:242830
Biological Process	GO:0010507	negative regulation of autophagy	IGI	J:242830
Biological Process	GO:0050866	negative regulation of cell activation	IDA	J:305994
Biological Process	GO:0010887	negative regulation of cholesterol storage	IMP	J:292426
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:284724
Biological Process	GO:0070345	negative regulation of fat cell proliferation	IMP	J:283590
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	IMP	J:304584
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:304584
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IMP	J:304584
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	IMP	J:273509
Biological Process	GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway	ISO	J:164563
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	IMP	J:304709
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	IMP	J:304588
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	ISO	J:164563
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	IDA	J:305994
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	IMP	J:284724
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	IMP	J:304588
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IMP	J:304584
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride	IMP	J:292426
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	IMP	J:304709
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	IMP	J:304709
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	IDA	J:305994
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:273509
Biological Process	GO:0150076	neuroinflammatory response	IMP	J:264653
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:164563
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:178250
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:215678
Biological Process	GO:0006911	phagocytosis, engulfment	IDA	J:144335
Biological Process	GO:0006910	phagocytosis, recognition	ISO	J:164563
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:277170
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:281622
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:281247
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	ISO	J:164563
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:242830
Biological Process	GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	ISO	J:164563
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	IMP	J:242830
Biological Process	GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway	ISO	J:164563
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IBA	J:265628
Biological Process	GO:1905291	positive regulation of CAMKK-AMPK signaling cascade	IGI	J:242830
Biological Process	GO:2000350	positive regulation of CD40 signaling pathway	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	IGI	J:243588
Biological Process	GO:0010875	positive regulation of cholesterol efflux	IMP	J:292426
Biological Process	GO:0045960	positive regulation of complement activation, classical pathway	IMP	J:273253
Biological Process	GO:1901076	positive regulation of engulfment of apoptotic cell	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:273509
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:1904951	positive regulation of establishment of protein localization	IMP	J:277170
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:256924
Biological Process	GO:0010983	positive regulation of high-density lipoprotein particle clearance	IMP	J:283590
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:273509
Biological Process	GO:1901980	positive regulation of inward rectifier potassium channel activity	IMP	J:260524
Biological Process	GO:0033674	positive regulation of kinase activity	ISO	J:164563
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance	IMP	J:283590
Biological Process	GO:0034241	positive regulation of macrophage fusion	IMP	J:258167
Biological Process	GO:1903980	positive regulation of microglial cell activation	IDA	J:284720
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:215678
Biological Process	GO:1903980	positive regulation of microglial cell activation	ISO	J:164563
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:277170
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:274782
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:272738
Biological Process	GO:1903980	positive regulation of microglial cell activation	IBA	J:265628
Biological Process	GO:1904141	positive regulation of microglial cell migration	IMP	J:243588
Biological Process	GO:1904141	positive regulation of microglial cell migration	IMP	J:277170
Biological Process	GO:1904141	positive regulation of microglial cell migration	IGI	J:260524
Biological Process	GO:1904141	positive regulation of microglial cell migration	ISO	J:164563
Biological Process	GO:1904141	positive regulation of microglial cell migration	IGI	J:243588
Biological Process	GO:1904141	positive regulation of microglial cell migration	IMP	J:266671
Biological Process	GO:0010822	positive regulation of mitochondrion organization	IMP	J:242830
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	IMP	J:274782
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:273509
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IMP	J:273549
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:292426
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:284720
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:284720
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:304584
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	ISO	J:164563
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IMP	J:272738
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IMP	J:274782
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IMP	J:305995
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	IMP	J:260524
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IGI	J:260524
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:1905808	positive regulation of synapse pruning	ISO	J:164563
Biological Process	GO:0032008	positive regulation of TOR signaling	IGI	J:242830
Biological Process	GO:0070269	pyroptosis	IMP	J:284724
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	IMP	J:304584
Biological Process	GO:0010468	regulation of gene expression	IMP	J:273253
Biological Process	GO:0010468	regulation of gene expression	IGI	J:260524
Biological Process	GO:0110089	regulation of hippocampal neuron apoptotic process	IMP	J:305995
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:273253
Biological Process	GO:0032675	regulation of interleukin-6 production	IGI	J:260524
Biological Process	GO:1902531	regulation of intracellular signal transduction	IGI	J:260524
Biological Process	GO:0019216	regulation of lipid metabolic process	ISO	J:164563
Biological Process	GO:0071640	regulation of macrophage inflammatory protein 1 alpha production	IGI	J:260524
Biological Process	GO:1903376	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP	J:305995
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IGI	J:260524
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IBA	J:265628
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	ISO	J:164563
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	IMP	J:266671
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	IMP	J:243588
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	IBA	J:265628
Biological Process	GO:0060075	regulation of resting membrane potential	IMP	J:260524
Biological Process	GO:0034151	regulation of toll-like receptor 6 signaling pathway	IMP	J:304709
Biological Process	GO:0032006	regulation of TOR signaling	IMP	J:242830
Biological Process	GO:0045728	respiratory burst after phagocytosis	IMP	J:273253
Biological Process	GO:0048678	response to axon injury	IMP	J:281622
Biological Process	GO:0048678	response to axon injury	ISO	J:164563
Biological Process	GO:0048678	response to axon injury	IMP	J:292426
Biological Process	GO:0002931	response to ischemia	IMP	J:273509
Biological Process	GO:0035176	social behavior	ISO	J:164563
Biological Process	GO:0035176	social behavior	IMP	J:272738

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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