GO Annotations Graph

• Symbol: Rgcc
• Name: regulator of cell cycle
• ID: MGI:1913464

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:183188
Molecular Function	GO:0005515	protein binding	IPI	J:73639
Molecular Function	GO:0030295	protein kinase activator activity	ISO	J:164563
Molecular Function	GO:0030295	protein kinase activator activity	IBA	J:265628
Molecular Function	GO:0030295	protein kinase activator activity	ISO	J:73639
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:73639
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:73639
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0006956	complement activation	ISO	J:164563
Biological Process	GO:0072537	fibroblast activation	IMP	J:183188
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ISO	J:73639
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	ISO	J:164563
Biological Process	GO:0001818	negative regulation of cytokine production	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0001100	negative regulation of exit from mitosis	ISO	J:164563
Biological Process	GO:0090272	negative regulation of fibroblast growth factor production	ISO	J:164563
Biological Process	GO:1901991	negative regulation of mitotic cell cycle phase transition	ISO	J:164563
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:164563
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:1901203	positive regulation of extracellular matrix assembly	ISO	J:164563
Biological Process	GO:0003331	positive regulation of extracellular matrix constituent secretion	ISO	J:164563
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IEA	J:72247