GO Annotations Graph

• Symbol: Iscu
• Name: iron-sulfur cluster assembly enzyme
• ID: MGI:1913633

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	IBA	J:265628
Molecular Function	GO:0008198	ferrous iron binding	IBA	J:265628
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:320071
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:1990229	iron-sulfur cluster assembly complex	NAS	J:320071
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	IDA	J:327042
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	IDA	J:326895
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	NAS	J:320072
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:129870
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0044571	[2Fe-2S] cluster assembly	ISO	J:164563
Biological Process	GO:0044571	[2Fe-2S] cluster assembly	ISO	J:164563
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	ISO	J:164563
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	IDA	J:326895
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	IBA	J:265628
Biological Process	GO:0016226	iron-sulfur cluster assembly	NAS	J:320071
Biological Process	GO:0016226	iron-sulfur cluster assembly	ISO	J:164563
Biological Process	GO:1904439	negative regulation of iron ion import across plasma membrane	ISO	J:164563
Biological Process	GO:1904234	positive regulation of aconitate hydratase activity	ISO	J:164563
Biological Process	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	ISO	J:164563