GO Annotations Graph

• Symbol: Mcm8
• Name: minichromosome maintenance 8 homologous recombination repair factor
• ID: MGI:1913884

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0032406	MutLbeta complex binding	ISO	J:164563
Molecular Function	GO:0032407	MutSalpha complex binding	ISO	J:164563
Molecular Function	GO:0032408	MutSbeta complex binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0003697	single-stranded DNA binding	IBA	J:265628
Molecular Function	GO:0017116	single-stranded DNA helicase activity	IBA	J:265628
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0042555	MCM complex	IBA	J:265628
Cellular Component	GO:0097362	MCM8-MCM9 complex	ISO	J:164563
Cellular Component	GO:0097362	MCM8-MCM9 complex	IDA	J:187623
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	IMP	J:187623
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0032508	DNA duplex unwinding	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006260	DNA replication	IEA	J:60000
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IMP	J:187623
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0007292	female gamete generation	IMP	J:187623
Biological Process	GO:0048232	male gamete generation	IMP	J:187623
Biological Process	GO:0071168	protein localization to chromatin	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0036298	recombinational interstrand cross-link repair	ISO	J:164563