GO Annotations Graph

• Symbol: Actr2
• Name: actin related protein 2
• ID: MGI:1913963

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:285722
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ISO	J:164563
Cellular Component	GO:0030478	actin cap	IDA	J:176957
Cellular Component	GO:0030478	actin cap	IDA	J:172280
Cellular Component	GO:0005885	Arp2/3 protein complex	ISO	J:164563
Cellular Component	GO:0005885	Arp2/3 protein complex	IBA	J:265628
Cellular Component	GO:0005938	cell cortex	IDA	J:172280
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:193447
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0061825	podosome core	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:176957
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	ISO	J:164563
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	IBA	J:265628
Biological Process	GO:0008356	asymmetric cell division	IGI	J:172280
Biological Process	GO:0071346	cellular response to type II interferon	IGI	J:143718
Biological Process	GO:0060271	cilium assembly	ISO	J:193447
Biological Process	GO:0016482	cytosolic transport	IMP	J:176957
Biological Process	GO:0007163	establishment or maintenance of cell polarity	IGI	J:172280
Biological Process	GO:0051321	meiotic cell cycle	IGI	J:172280
Biological Process	GO:0016344	meiotic chromosome movement towards spindle pole	IGI	J:195195
Biological Process	GO:0033206	meiotic cytokinesis	IGI	J:172280
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0051653	spindle localization	IGI	J:172280