GO Annotations Graph

• Symbol: Lrrk2
• Name: leucine-rich repeat kinase 2
• ID: MGI:1913975

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:1904713	beta-catenin destruction complex binding	IPI	J:188340
Molecular Function	GO:0030276	clathrin binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	ISO	J:113152
Molecular Function	GO:0034211	GTP-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0034211	GTP-dependent protein kinase activity	ISO	J:113152
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	IPI	J:196230
Molecular Function	GO:0042802	identical protein binding	IPI	J:196255
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:235302
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0036479	peroxidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:183409
Molecular Function	GO:0005515	protein binding	IPI	J:209576
Molecular Function	GO:0005515	protein binding	IPI	J:183203
Molecular Function	GO:0005515	protein binding	IPI	J:277876
Molecular Function	GO:0005515	protein binding	IPI	J:206832
Molecular Function	GO:0005515	protein binding	IPI	J:233567
Molecular Function	GO:0005515	protein binding	IPI	J:188340
Molecular Function	GO:0005515	protein binding	IPI	J:188340
Molecular Function	GO:0005515	protein binding	IPI	J:169453
Molecular Function	GO:0005515	protein binding	IPI	J:277870
Molecular Function	GO:0005515	protein binding	IPI	J:204661
Molecular Function	GO:0005515	protein binding	IPI	J:216361
Molecular Function	GO:0005515	protein binding	IPI	J:186257
Molecular Function	GO:0005515	protein binding	IPI	J:196255
Molecular Function	GO:0005515	protein binding	IPI	J:213877
Molecular Function	GO:0005515	protein binding	IPI	J:259183
Molecular Function	GO:0005515	protein binding	IPI	J:239897
Molecular Function	GO:0005515	protein binding	IPI	J:206826
Molecular Function	GO:0005515	protein binding	IPI	J:206826
Molecular Function	GO:0005515	protein binding	IPI	J:241450
Molecular Function	GO:0005515	protein binding	IPI	J:183238
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0051018	protein kinase A binding	IPI	J:206832
Molecular Function	GO:0051018	protein kinase A binding	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:206826
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:259183
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:73065
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:241450
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:241450
Molecular Function	GO:0044877	protein-containing complex binding	IC	J:233567
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	ISO	J:164563
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	IC	J:188340
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IPI	J:183203
Molecular Function	GO:0000149	SNARE binding	ISO	J:164563
Molecular Function	GO:0000149	SNARE binding	IBA	J:265628
Molecular Function	GO:0017075	syntaxin-1 binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0015631	tubulin binding	ISO	J:164563
Cellular Component	GO:0044753	amphisome	ISO	J:164563
Cellular Component	GO:0044754	autolysosome	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	IBA	J:265628
Cellular Component	GO:0099400	caveola neck	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:239897
Cellular Component	GO:0032473	cytoplasmic side of mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:210913
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:241450
Cellular Component	GO:0030425	dendrite	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:206832
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:210913
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0070971	endoplasmic reticulum exit site	ISO	J:164563
Cellular Component	GO:0070971	endoplasmic reticulum exit site	IDA	J:216361
Cellular Component	GO:0005768	endosome	IDA	J:210913
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263463
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263463
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263463
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263463
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:210913
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005798	Golgi-associated vesicle	ISO	J:164563
Cellular Component	GO:0030426	growth cone	ISO	J:164563
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:210913
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	IDA	J:121772
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:210913
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:210913
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	IDA	J:210913
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0097487	multivesicular body, internal vesicle	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:164563
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:121772
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:121772
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:121772
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:121772
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:121772
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:121772
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:121772
Cellular Component	GO:1990904	ribonucleoprotein complex	IDA	J:211935
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:183238
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:121772
Cellular Component	GO:0043195	terminal bouton	IC	J:169453
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:206826
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:121772
Cellular Component	GO:1990909	Wnt signalosome	IDA	J:188340
Cellular Component	GO:1990909	Wnt signalosome	ISO	J:164563
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0019722	calcium-mediated signaling	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:1903351	cellular response to dopamine	ISO	J:164563
Biological Process	GO:0071287	cellular response to manganese ion	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0009267	cellular response to starvation	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0008340	determination of adult lifespan	ISO	J:164563
Biological Process	GO:0006897	endocytosis	ISO	J:164563
Biological Process	GO:0007029	endoplasmic reticulum organization	IMP	J:216361
Biological Process	GO:0007029	endoplasmic reticulum organization	ISO	J:164563
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:206832
Biological Process	GO:0035640	exploration behavior	ISO	J:164563
Biological Process	GO:0007030	Golgi organization	ISO	J:164563
Biological Process	GO:0007030	Golgi organization	IGI	J:206826
Biological Process	GO:0046039	GTP metabolic process	ISO	J:164563
Biological Process	GO:0048312	intracellular distribution of mitochondria	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:206832
Biological Process	GO:0007254	JNK cascade	ISO	J:164563
Biological Process	GO:0035641	locomotory exploration behavior	IMP	J:206832
Biological Process	GO:0007040	lysosome organization	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0051646	mitochondrion localization	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	IBA	J:265628
Biological Process	GO:1902902	negative regulation of autophagosome assembly	ISO	J:164563
Biological Process	GO:1902902	negative regulation of autophagosome assembly	IBA	J:265628
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	IMP	J:169453
Biological Process	GO:0034260	negative regulation of GTPase activity	ISO	J:183238
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	ISO	J:164563
Biological Process	GO:0016242	negative regulation of macroautophagy	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:206832
Biological Process	GO:0010955	negative regulation of protein processing	ISO	J:164563
Biological Process	GO:1903215	negative regulation of protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0007528	neuromuscular junction development	ISO	J:164563
Biological Process	GO:0070997	neuron death	ISO	J:164563
Biological Process	GO:0140058	neuron projection arborization	ISO	J:155856
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:164563
Biological Process	GO:0021772	olfactory bulb development	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:160542
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060161	positive regulation of dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:1903980	positive regulation of microglial cell activation	ISO	J:155856
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISO	J:155856
Biological Process	GO:0043068	positive regulation of programmed cell death	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	J:160542
Biological Process	GO:1902499	positive regulation of protein autoubiquitination	ISO	J:164563
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:113152
Biological Process	GO:0006606	protein import into nucleus	IMP	J:241450
Biological Process	GO:0006606	protein import into nucleus	IDA	J:241450
Biological Process	GO:0008104	protein localization	IMP	J:206832
Biological Process	GO:0070973	protein localization to endoplasmic reticulum exit site	IMP	J:216361
Biological Process	GO:0070973	protein localization to endoplasmic reticulum exit site	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IMP	J:259183
Biological Process	GO:0006468	protein phosphorylation	ISO	J:113152
Biological Process	GO:0006468	protein phosphorylation	IMP	J:241450
Biological Process	GO:0006468	protein phosphorylation	IDA	J:241450
Biological Process	GO:0072593	reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	ISO	J:164563
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve	ISO	J:164563
Biological Process	GO:1905289	regulation of CAMKK-AMPK signaling cascade	ISO	J:164563
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	IPI	J:188340
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	IGI	J:206832
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	ISO	J:164563
Biological Process	GO:0060159	regulation of dopamine receptor signaling pathway	IMP	J:206832
Biological Process	GO:0060628	regulation of ER to Golgi vesicle-mediated transport	IMP	J:216361
Biological Process	GO:0010468	regulation of gene expression	IMP	J:211935
Biological Process	GO:0035564	regulation of kidney size	IMP	J:160542
Biological Process	GO:0040012	regulation of locomotion	ISO	J:164563
Biological Process	GO:0035751	regulation of lysosomal lumen pH	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0051900	regulation of mitochondrial depolarization	ISO	J:164563
Biological Process	GO:1902692	regulation of neuroblast proliferation	ISO	J:164563
Biological Process	GO:1901214	regulation of neuron death	ISO	J:164563
Biological Process	GO:0014041	regulation of neuron maturation	ISO	J:164563
Biological Process	GO:0010738	regulation of protein kinase A signaling	IMP	J:206832
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:1905279	regulation of retrograde transport, endosome to Golgi	ISO	J:164563
Biological Process	GO:1905279	regulation of retrograde transport, endosome to Golgi	IBA	J:265628
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IMP	J:206832
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IMP	J:263463
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:263463
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:263463
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:263463
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:263463
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IMP	J:263463
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:263463
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:263463
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	ISO	J:164563
Biological Process	GO:1902803	regulation of synaptic vesicle transport	IMP	J:169453
Biological Process	GO:1902803	regulation of synaptic vesicle transport	IBA	J:265628
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0036465	synaptic vesicle recycling	TAS	J:169453
Biological Process	GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	ISO	J:164563
Biological Process	GO:1904887	Wnt signalosome assembly	IC	J:188340
Biological Process	GO:1904887	Wnt signalosome assembly	ISO	J:164563