GO Annotations Graph

• Symbol: Wwp2
• Name: WW domain containing E3 ubiquitin protein ligase 2
• ID: MGI:1914144

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:205660
Molecular Function	GO:0005515	protein binding	IPI	J:205660
Molecular Function	GO:0005515	protein binding	IPI	J:284781
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:168207
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IGI	J:205660
Molecular Function	GO:0008134	transcription factor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:168207
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IDA	J:163434
Cellular Component	GO:0005737	cytoplasm	IDA	J:168207
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:168207
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:205660
Biological Process	GO:0006858	extracellular transport	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:168207
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:168207
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0051224	negative regulation of protein transport	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:168207
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032410	negative regulation of transporter activity	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:205660
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:205660
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:163434
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	IMP	J:163434
Biological Process	GO:0070534	protein K63-linked ubiquitination	IBA	J:265628
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IDA	J:168207
Biological Process	GO:0016567	protein ubiquitination	ISO	J:227354
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IBA	J:265628
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:205660
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:205660
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	J:72247