GO Annotations Graph

• Symbol: Cul4a
• Name: cullin 4A
• ID: MGI:1914487

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:331350
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:132869
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	EXP	J:320034
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	IBA	J:265628
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	ISO	J:73065
Cellular Component	GO:0031461	cullin-RING ubiquitin ligase complex	IEA	J:72247
Cellular Component	GO:0005634	nucleus	NAS	J:320034
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IDA	J:132869
Biological Process	GO:0034644	cellular response to UV	EXP	J:320034
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	EXP	J:320034
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IBA	J:265628
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0030097	hemopoiesis	IMP	J:138468
Biological Process	GO:0001701	in utero embryonic development	IMP	J:78032
Biological Process	GO:0030853	negative regulation of granulocyte differentiation	IDA	J:115558
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:132869
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IMP	J:142037
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:142037
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	J:132869
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:2000001	regulation of DNA damage checkpoint	IMP	J:150427
Biological Process	GO:2000819	regulation of nucleotide-excision repair	IMP	J:150427
Biological Process	GO:0051246	regulation of protein metabolic process	IMP	J:142037
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0042254	ribosome biogenesis	IMP	J:273532
Biological Process	GO:0042254	ribosome biogenesis	ISO	J:164563
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:147012
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:150427