GO Annotations Graph

• Symbol: Smc6
• Name: structural maintenance of chromosomes 6
• ID: MGI:1914491

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0140664	ATP-dependent DNA damage sensor activity	IEA	J:72247
Molecular Function	GO:0003684	damaged DNA binding	IBA	J:265628
Molecular Function	GO:0000217	DNA secondary structure binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0003697	single-stranded DNA binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:240155
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:240155
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:240155
Cellular Component	GO:0000781	chromosome, telomeric region	TAS	J:238456
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0035061	interchromatin granule	ISO	J:164563
Cellular Component	GO:0097431	mitotic spindle pole	IDA	J:240155
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:240155
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0016605	PML body	TAS	J:238456
Cellular Component	GO:0000803	sex chromosome	IDA	J:162301
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	IBA	J:265628
Cellular Component	GO:0030915	Smc5-Smc6 complex	ISO	J:164563
Cellular Component	GO:0030915	Smc5-Smc6 complex	IBA	J:265628
Cellular Component	GO:0030915	Smc5-Smc6 complex	IDA	J:240155
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006310	DNA recombination	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0044828	negative regulation by host of viral genome replication	ISO	J:164563
Biological Process	GO:0051984	positive regulation of chromosome segregation	ISO	J:164563
Biological Process	GO:0000722	telomere maintenance via recombination	ISO	J:164563