GO Annotations Graph

• Symbol: Abcg8
• Name: ATP binding cassette subfamily G member 8
• ID: MGI:1914720

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140359	ABC-type transporter activity	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0120020	cholesterol transfer activity	IMP	J:86723
Molecular Function	GO:0120020	cholesterol transfer activity	ISO	J:164563
Molecular Function	GO:0120020	cholesterol transfer activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:248556
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:248556
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:248556
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IMP	J:86723
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:116923
Cellular Component	GO:0043190	ATP-binding cassette (ABC) transporter complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:248556
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IDA	J:86723
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0033344	cholesterol efflux	ISO	J:164563
Biological Process	GO:0033344	cholesterol efflux	IMP	J:86723
Biological Process	GO:0033344	cholesterol efflux	IBA	J:265628
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IBA	J:265628
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:94759
Biological Process	GO:0030299	intestinal cholesterol absorption	IC	J:78963
Biological Process	GO:0006869	lipid transport	IEA	J:60000
Biological Process	GO:0045796	negative regulation of intestinal cholesterol absorption	ISO	J:164563
Biological Process	GO:0010949	negative regulation of intestinal phytosterol absorption	ISO	J:164563
Biological Process	GO:0015914	phospholipid transport	IMP	J:94759
Biological Process	GO:0055092	sterol homeostasis	IMP	J:94759
Biological Process	GO:0015918	sterol transport	IDA	J:116923
Biological Process	GO:0015918	sterol transport	IMP	J:94759
Biological Process	GO:0055085	transmembrane transport	IBA	J:265628