GO Annotations Graph

• Symbol: Atg12
• Name: autophagy related 12
• ID: MGI:1914776

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:245241
Molecular Function	GO:0005515	protein binding	IPI	J:70539
Molecular Function	GO:0005515	protein binding	IPI	J:83346
Molecular Function	GO:0005515	protein binding	IPI	J:164739
Molecular Function	GO:0005515	protein binding	IPI	J:80842
Molecular Function	GO:0005515	protein binding	IPI	J:75687
Molecular Function	GO:0005515	protein binding	IPI	J:80842
Cellular Component	GO:0034274	Atg12-Atg5-Atg16 complex	ISO	J:164563
Cellular Component	GO:0034274	Atg12-Atg5-Atg16 complex	IDA	J:83346
Cellular Component	GO:0034274	Atg12-Atg5-Atg16 complex	IBA	J:265628
Cellular Component	GO:0005776	autophagosome	ISO	J:215480
Cellular Component	GO:0005737	cytoplasm	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5682660
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5682677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5683594
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-936387
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IMP	J:156519
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0034045	phagophore assembly site membrane	IDA	J:83346
Cellular Component	GO:0034045	phagophore assembly site membrane	IDA	J:70539
Cellular Component	GO:0034045	phagophore assembly site membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	NAS	J:319961
Cellular Component	GO:1990234	transferase complex	IDA	J:164739
Biological Process	GO:0000045	autophagosome assembly	IMP	J:70539
Biological Process	GO:0000045	autophagosome assembly	IBA	J:265628
Biological Process	GO:0006914	autophagy	ISO	J:155856
Biological Process	GO:0006914	autophagy	TAS	J:75687
Biological Process	GO:0000422	autophagy of mitochondrion	IBA	J:265628
Biological Process	GO:0044804	autophagy of nucleus	IBA	J:265628
Biological Process	GO:0006501	C-terminal protein lipidation	IBA	J:265628
Biological Process	GO:0016236	macroautophagy	IMP	J:70539
Biological Process	GO:0016236	macroautophagy	ISO	J:164563
Biological Process	GO:0050687	negative regulation of defense response to virus	ISO	J:164563
Biological Process	GO:0050687	negative regulation of defense response to virus	IDA	J:124905
Biological Process	GO:0045824	negative regulation of innate immune response	IDA	J:124905
Biological Process	GO:0032480	negative regulation of type I interferon production	IDA	J:124905
Biological Process	GO:1904973	positive regulation of viral translation	ISO	J:164563
Biological Process	GO:0006497	protein lipidation	ISO	J:164563
Biological Process	GO:1901096	regulation of autophagosome maturation	ISO	J:164563