GO Annotations Graph

• Symbol: Derl1
• Name: Der1-like domain family, member 1
• ID: MGI:1915069

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042288	MHC class I protein binding	ISO	J:164563
Molecular Function	GO:0051787	misfolded protein binding	IBA	J:265628
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:198900
Molecular Function	GO:0005515	protein binding	IPI	J:215393
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0005047	signal recognition particle binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:1990381	ubiquitin-specific protease binding	ISO	J:164563
Molecular Function	GO:1990381	ubiquitin-specific protease binding	IBA	J:265628
Cellular Component	GO:0036513	Derlin-1 retrotranslocation complex	ISO	J:164563
Cellular Component	GO:0036502	Derlin-1-VIMP complex	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IDA	J:153178
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:153178
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:73065
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	IDA	J:296101
Cellular Component	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex	IBA	J:265628
Cellular Component	GO:0005770	late endosome	IDA	J:153178
Cellular Component	GO:0016020	membrane	ISO	J:73065
Biological Process	GO:0034620	cellular response to unfolded protein	IMP	J:153178
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	ISO	J:164563
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IBA	J:265628
Biological Process	GO:0071712	ER-associated misfolded protein catabolic process	ISO	J:164563
Biological Process	GO:0036503	ERAD pathway	ISO	J:164563
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:233169
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0006986	response to unfolded protein	ISO	J:73065
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	ISO	J:73065
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	ISO	J:164563
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	IBA	J:265628