GO Annotations Graph

• Symbol: Npc2
• Name: NPC intracellular cholesterol transporter 2
• ID: MGI:1915213

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015485	cholesterol binding	ISO	J:164563
Molecular Function	GO:0015485	cholesterol binding	IMP	J:192648
Molecular Function	GO:0015485	cholesterol binding	ISS	J:127209
Molecular Function	GO:0015485	cholesterol binding	IBA	J:265628
Molecular Function	GO:0120020	cholesterol transfer activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISS	J:127190
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:170933
Cellular Component	GO:0005764	lysosome	IDA	J:261411
Biological Process	GO:0033344	cholesterol efflux	IMP	J:192648
Biological Process	GO:0033344	cholesterol efflux	ISO	J:164563
Biological Process	GO:0033344	cholesterol efflux	IBA	J:265628
Biological Process	GO:0042632	cholesterol homeostasis	ISS	J:127188
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0010878	cholesterol storage	IMP	J:170933
Biological Process	GO:0030301	cholesterol transport	IMP	J:192648
Biological Process	GO:0030301	cholesterol transport	ISS	J:127209
Biological Process	GO:0030301	cholesterol transport	ISO	J:164563
Biological Process	GO:0010467	gene expression	IMP	J:170933
Biological Process	GO:0032367	intracellular cholesterol transport	IMP	J:127209
Biological Process	GO:0032367	intracellular cholesterol transport	IBA	J:265628
Biological Process	GO:0032367	intracellular cholesterol transport	ISO	J:73065
Biological Process	GO:0032366	intracellular sterol transport	ISS	J:127209
Biological Process	GO:0032366	intracellular sterol transport	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006869	lipid transport	IEA	J:60000
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0016125	sterol metabolic process	IMP	J:170933
Biological Process	GO:0015918	sterol transport	IMP	J:170933