GO Annotations Graph

• Symbol: Brk1
• Name: BRICK1, SCAR/WAVE actin-nucleating complex subunit
• ID: MGI:1915406

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0030027	lamellipodium	IDA	J:205674
Cellular Component	GO:0031209	SCAR complex	ISO	J:164563
Cellular Component	GO:0031209	SCAR complex	IBA	J:265628
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:166082
Biological Process	GO:0007015	actin filament organization	IEA	J:72247
Biological Process	GO:0048870	cell motility	IBA	J:265628
Biological Process	GO:0048870	cell motility	IMP	J:166082
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:166082
Biological Process	GO:0001701	in utero embryonic development	IMP	J:166082
Biological Process	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:166082
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0016601	Rac protein signal transduction	ISO	J:164563
Biological Process	GO:0008064	regulation of actin polymerization or depolymerization	IBA	J:265628