GO Annotations Graph

• Symbol: Rtn4
• Name: reticulon 4
• ID: MGI:1915835

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045296	cadherin binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:228796
Molecular Function	GO:0005515	protein binding	IPI	J:208445
Molecular Function	GO:0005515	protein binding	IPI	J:286567
Molecular Function	GO:0005515	protein binding	IPI	J:202700
Molecular Function	GO:0005515	protein binding	IPI	J:269559
Molecular Function	GO:0005515	protein binding	IPI	J:68902
Molecular Function	GO:0005515	protein binding	IPI	J:148628
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IDA	J:91015
Cellular Component	GO:0042995	cell projection	IDA	J:91015
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:278382
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:79814
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:228796
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:269544
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISS	J:113876
Cellular Component	GO:0071782	endoplasmic reticulum tubular network	ISO	J:164563
Cellular Component	GO:0098826	endoplasmic reticulum tubular network membrane	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:265812
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:265812
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:265812
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:265812
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043209	myelin sheath	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	ISS	J:113882
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	IMP	J:265812
Cellular Component	GO:0098794	postsynapse	IDA	J:265812
Cellular Component	GO:0098794	postsynapse	IDA	J:265812
Cellular Component	GO:0098794	postsynapse	IDA	J:265812
Cellular Component	GO:0098794	postsynapse	IDA	J:265812
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0007413	axonal fasciculation	IMP	J:163856
Biological Process	GO:0007413	axonal fasciculation	ISO	J:155856
Biological Process	GO:0001825	blastocyst formation	IMP	J:244597
Biological Process	GO:0007420	brain development	IBA	J:265628
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	IMP	J:161350
Biological Process	GO:0120078	cell adhesion involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0035441	cell migration involved in vasculogenesis	IMP	J:197333
Biological Process	GO:0071456	cellular response to hypoxia	IDA	J:269555
Biological Process	GO:0022009	central nervous system vasculogenesis	IMP	J:197333
Biological Process	GO:0021801	cerebral cortex radial glia-guided migration	IMP	J:161875
Biological Process	GO:0007029	endoplasmic reticulum organization	ISO	J:164563
Biological Process	GO:0071787	endoplasmic reticulum tubular network formation	ISO	J:164563
Biological Process	GO:0071787	endoplasmic reticulum tubular network formation	IBA	J:265628
Biological Process	GO:1990809	endoplasmic reticulum tubular network membrane organization	ISO	J:164563
Biological Process	GO:0071786	endoplasmic reticulum tubular network organization	ISO	J:164563
Biological Process	GO:0090156	intracellular sphingolipid homeostasis	IMP	J:228796
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	IMP	J:169605
Biological Process	GO:0050804	modulation of chemical synaptic transmission	EXP	J:265812
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:265812
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:265812
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:265812
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0030517	negative regulation of axon extension	ISO	J:164563
Biological Process	GO:0030517	negative regulation of axon extension	IMP	J:163856
Biological Process	GO:0030517	negative regulation of axon extension	ISS	J:113876
Biological Process	GO:0030517	negative regulation of axon extension	ISO	J:155856
Biological Process	GO:0050771	negative regulation of axonogenesis	ISO	J:155856
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0070571	negative regulation of neuron projection regeneration	ISO	J:155856
Biological Process	GO:2001213	negative regulation of vasculogenesis	IMP	J:197333
Biological Process	GO:0007399	nervous system development	IDA	J:79814
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0051292	nuclear pore complex assembly	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:153670
Biological Process	GO:1905653	positive regulation of artery morphogenesis	IMP	J:153670
Biological Process	GO:0033603	positive regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:1905580	positive regulation of ERBB3 signaling pathway	ISO	J:164563
Biological Process	GO:0045687	positive regulation of glial cell differentiation	ISO	J:155856
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	IMP	J:271690
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:153670
Biological Process	GO:1905523	positive regulation of macrophage migration	IMP	J:153670
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	ISO	J:164563
Biological Process	GO:1902624	positive regulation of neutrophil migration	IMP	J:169605
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1905552	positive regulation of protein localization to endoplasmic reticulum	ISO	J:164563
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	IMP	J:153670
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	IMP	J:269559
Biological Process	GO:0061462	protein localization to lysosome	IMP	J:269559
Biological Process	GO:0050821	protein stabilization	IMP	J:240367
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve	ISO	J:155856
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve	IMP	J:163856
Biological Process	GO:0030334	regulation of cell migration	ISO	J:73065
Biological Process	GO:0051960	regulation of nervous system development	IMP	J:163856
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856