GO Annotations Graph

• Symbol: Trpm4
• Name: transient receptor potential cation channel, subfamily M, member 4
• ID: MGI:1915917

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IDA	J:257315
Molecular Function	GO:0005227	calcium activated cation channel activity	IDA	J:166018
Molecular Function	GO:0005227	calcium activated cation channel activity	IDA	J:257315
Molecular Function	GO:0005227	calcium activated cation channel activity	ISO	J:155856
Molecular Function	GO:0005227	calcium activated cation channel activity	ISO	J:164563
Molecular Function	GO:0005227	calcium activated cation channel activity	IBA	J:265628
Molecular Function	GO:0005227	calcium activated cation channel activity	ISO	J:84761
Molecular Function	GO:0005262	calcium channel activity	IDA	J:84948
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0099604	ligand-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	ISO	J:84761
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:84761
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:257315
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9717432
Cellular Component	GO:0005886	plasma membrane	IDA	J:84948
Cellular Component	GO:0034706	sodium channel complex	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0070588	calcium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006816	calcium ion transport	IDA	J:84948
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0061337	cardiac conduction	IEA	J:72247
Biological Process	GO:0071318	cellular response to ATP	IDA	J:257315
Biological Process	GO:0002407	dendritic cell chemotaxis	IMP	J:140991
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0098662	inorganic cation transmembrane transport	IDA	J:257315
Biological Process	GO:0098662	inorganic cation transmembrane transport	ISO	J:164563
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0086045	membrane depolarization during AV node cell action potential	ISO	J:164563
Biological Process	GO:0086048	membrane depolarization during bundle of His cell action potential	ISO	J:164563
Biological Process	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential	ISO	J:164563
Biological Process	GO:0006812	monoatomic cation transport	IEA	J:72247
Biological Process	GO:0034220	monoatomic ion transmembrane transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0030502	negative regulation of bone mineralization	ISO	J:155856
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:1904179	positive regulation of adipose tissue development	ISO	J:155856
Biological Process	GO:1903949	positive regulation of atrial cardiac muscle cell action potential	ISO	J:155856
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:155856
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:1904199	positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0051289	protein homotetramerization	IDA	J:257315
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0016925	protein sumoylation	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:84761
Biological Process	GO:0002724	regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0098719	sodium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0042310	vasoconstriction	IEA	J:72247