GO Annotations Graph

• Symbol: Dusp22
• Name: dual specificity phosphatase 22
• ID: MGI:1915926

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0017018	myosin phosphatase activity	IEA	J:72245
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0016791	phosphatase activity	IEA	J:72247
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:79283
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	IEA	J:72245
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	IPI	J:213253
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IBA	J:265628
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:213253
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	ISO	J:79283
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0031941	filamentous actin	ISO	J:164563
Cellular Component	GO:0061851	leading edge of lamellipodium	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:164563
Biological Process	GO:0016311	dephosphorylation	IBA	J:265628
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:1903996	negative regulation of non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0050868	negative regulation of T cell activation	IMP	J:213253
Biological Process	GO:0002710	negative regulation of T cell mediated immunity	IMP	J:213253
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	IMP	J:213253
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:79283
Biological Process	GO:0006470	protein dephosphorylation	IEA	J:72247
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:79283
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:79283