GO Annotations Graph

• Symbol: Smpdl3b
• Name: sphingomyelin phosphodiesterase, acid-like 3B
• ID: MGI:1916022

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IMP	J:224870
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	ISO	J:164563
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IDA	J:271707
Molecular Function	GO:0005515	protein binding	IPI	J:224870
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	IEA	J:72247
Molecular Function	GO:0008270	zinc ion binding	IDA	J:271707
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:224870
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0046466	membrane lipid catabolic process	IMP	J:224870
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:224870
Biological Process	GO:0045824	negative regulation of innate immune response	TAS	J:224870
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	IMP	J:224870
Biological Process	GO:0006685	sphingomyelin catabolic process	IEA	J:72247