GO Annotations Graph

• Symbol: Pink1
• Name: PTEN induced putative kinase 1
• ID: MGI:1916193

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IDA	J:100301
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0055131	C3HC4-type RING finger domain binding	ISO	J:164563
Molecular Function	GO:0010857	calcium-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IDA	J:100301
Molecular Function	GO:0016301	kinase activity	ISO	J:73065
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:100301
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:282679
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0043422	protein kinase B binding	ISO	J:164563
Molecular Function	GO:0106310	protein serine kinase activity	IMP	J:302474
Molecular Function	GO:0106310	protein serine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:211292
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:100301
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:218298
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:209583
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:1904841	TORC2 complex binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0097449	astrocyte projection	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0044297	cell body	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9621286
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:282679
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:209583
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:164563
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:282679
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:73065
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0000422	autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0000422	autophagy of mitochondrion	IBA	J:265628
Biological Process	GO:0050432	catecholamine secretion	IMP	J:122728
Biological Process	GO:1904881	cellular response to hydrogen sulfide	ISO	J:155856
Biological Process	GO:0071456	cellular response to hypoxia	IMP	J:207460
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:140335
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0097237	cellular response to toxic substance	IMP	J:186202
Biological Process	GO:0014046	dopamine secretion	IMP	J:122728
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:122728
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:122728
Biological Process	GO:0072655	establishment of protein localization to mitochondrion	ISO	J:164563
Biological Process	GO:0030097	hemopoiesis	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:100301
Biological Process	GO:0072656	maintenance of protein location in mitochondrion	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	ISO	J:164563
Biological Process	GO:0099074	mitochondrion to lysosome transport	ISO	J:164563
Biological Process	GO:0000423	mitophagy	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1902902	negative regulation of autophagosome assembly	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:212717
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IMP	J:207460
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0016242	negative regulation of macroautophagy	ISO	J:164563
Biological Process	GO:0090258	negative regulation of mitochondrial fission	ISO	J:164563
Biological Process	GO:1901525	negative regulation of mitophagy	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:148903
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:186202
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:1903202	negative regulation of oxidative stress-induced cell death	ISO	J:164563
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	ISO	J:155856
Biological Process	GO:0033605	positive regulation of catecholamine secretion	IMP	J:122728
Biological Process	GO:1903852	positive regulation of cristae formation	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:207460
Biological Process	GO:0033603	positive regulation of dopamine secretion	IMP	J:122728
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0016239	positive regulation of macroautophagy	ISO	J:164563
Biological Process	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	IMP	J:209583
Biological Process	GO:0090141	positive regulation of mitochondrial fission	ISO	J:155856
Biological Process	GO:0090141	positive regulation of mitochondrial fission	IBA	J:265628
Biological Process	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	ISO	J:164563
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	IMP	J:207460
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0032226	positive regulation of synaptic transmission, dopaminergic	IMP	J:122728
Biological Process	GO:0045727	positive regulation of translation	IMP	J:207460
Biological Process	GO:0006468	protein phosphorylation	IDA	J:100301
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:333006
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0050821	protein stabilization	IMP	J:146282
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	IBA	J:265628
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0010310	regulation of hydrogen peroxide metabolic process	IMP	J:207460
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	ISO	J:164563
Biological Process	GO:0010821	regulation of mitochondrion organization	ISO	J:164563
Biological Process	GO:0043523	regulation of neuron apoptotic process	IMP	J:186202
Biological Process	GO:0002082	regulation of oxidative phosphorylation	ISO	J:164563
Biological Process	GO:1903214	regulation of protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:0031396	regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0022904	respiratory electron transport chain	IMP	J:140335
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563