GO Annotations Graph

• Symbol: Insig1
• Name: insulin induced gene 1
• ID: MGI:1916289

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0008142	oxysterol binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:79403
Molecular Function	GO:0005515	protein binding	IPI	J:79403
Molecular Function	GO:0140311	protein sequestering activity	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	TAS	J:79403
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0032937	SREBP-SCAP-Insig complex	ISO	J:164563
Cellular Component	GO:0032937	SREBP-SCAP-Insig complex	IBA	J:265628
Biological Process	GO:0032869	cellular response to insulin stimulus	IBA	J:265628
Biological Process	GO:0036315	cellular response to sterol	ISO	J:164563
Biological Process	GO:0006695	cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0006695	cholesterol biosynthetic process	IBA	J:265628
Biological Process	GO:0006695	cholesterol biosynthetic process	IGI	J:114535
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IGI	J:101203
Biological Process	GO:0060363	cranial suture morphogenesis	IGI	J:114535
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:114535
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0042474	middle ear morphogenesis	IGI	J:114535
Biological Process	GO:1901303	negative regulation of cargo loading into COPII-coated vesicle	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IDA	J:84786
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	IGI	J:101203
Biological Process	GO:0070862	negative regulation of protein exit from endoplasmic reticulum	ISO	J:164563
Biological Process	GO:0010894	negative regulation of steroid biosynthetic process	IGI	J:101203
Biological Process	GO:0006991	response to sterol depletion	IDA	J:79403
Biological Process	GO:0060021	roof of mouth development	IGI	J:114535
Biological Process	GO:0032933	SREBP signaling pathway	ISO	J:164563
Biological Process	GO:0032933	SREBP signaling pathway	IBA	J:265628
Biological Process	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	ISO	J:164563
Biological Process	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	IBA	J:265628
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0016126	sterol biosynthetic process	IGI	J:114535
Biological Process	GO:0006641	triglyceride metabolic process	IGI	J:101203