GO Annotations Graph

• Symbol: Gsdmd
• Name: gasdermin D
• ID: MGI:1916396

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1901612	cardiolipin binding	IDA	J:235300
Molecular Function	GO:0099103	channel activator activity	IDA	J:235300
Molecular Function	GO:0099103	channel activator activity	IDA	J:235300
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0070300	phosphatidic acid binding	IDA	J:235300
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IBA	J:265628
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:235300
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:235300
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:235300
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:235300
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	ISO	J:164563
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	IDA	J:235300
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	IBA	J:265628
Molecular Function	GO:0001786	phosphatidylserine binding	IDA	J:235300
Molecular Function	GO:0001786	phosphatidylserine binding	IBA	J:265628
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:261341
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:319941
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:259899
Molecular Function	GO:0022829	wide pore channel activity	ISO	J:164563
Molecular Function	GO:0022829	wide pore channel activity	ISO	J:164563
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:296127
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:326897
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:326897
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:234332
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:235300
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:235300
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:235300
Cellular Component	GO:0061702	canonical inflammasome complex	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:235300
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:235300
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0072559	NLRP3 inflammasome complex	IDA	J:229325
Cellular Component	GO:0072559	NLRP3 inflammasome complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:326897
Cellular Component	GO:0005886	plasma membrane	IDA	J:235300
Cellular Component	GO:0005886	plasma membrane	IDA	J:234332
Cellular Component	GO:0005886	plasma membrane	IDA	J:235300
Cellular Component	GO:0005886	plasma membrane	IDA	J:235300
Cellular Component	GO:0005886	plasma membrane	IDA	J:235300
Biological Process	GO:0031668	cellular response to extracellular stimulus	IDA	J:54434
Biological Process	GO:0042742	defense response to bacterium	IBA	J:265628
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IDA	J:235300
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IDA	J:235300
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0046931	pore complex assembly	IDA	J:235300
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:235300
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:235300
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:235300
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:259899
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:319941
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:229325
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:261341
Biological Process	GO:0032732	positive regulation of interleukin-1 production	ISO	J:164563
Biological Process	GO:0032741	positive regulation of interleukin-18 production	ISO	J:164563
Biological Process	GO:0012501	programmed cell death	IEA	J:60000
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	IDA	J:235300
Biological Process	GO:0009306	protein secretion	ISO	J:164563
Biological Process	GO:0009306	protein secretion	IDA	J:326897
Biological Process	GO:0070269	pyroptosis	IDA	J:296118
Biological Process	GO:0070269	pyroptosis	IDA	J:229325
Biological Process	GO:0070269	pyroptosis	IDA	J:296122
Biological Process	GO:0070269	pyroptosis	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	IDA	J:296114
Biological Process	GO:0070269	pyroptosis	IDA	J:296127
Biological Process	GO:0070269	pyroptosis	IBA	J:265628
Biological Process	GO:0070269	pyroptosis	IDA	J:326897
Biological Process	GO:0070269	pyroptosis	IDA	J:235300
Biological Process	GO:0070269	pyroptosis	IDA	J:234332
Biological Process	GO:0070269	pyroptosis	IDA	J:235300
Biological Process	GO:0070269	pyroptosis	IDA	J:235300
Biological Process	GO:0070269	pyroptosis	IDA	J:235300