GO Annotations Graph

• Symbol: Esam
• Name: endothelial cell-specific adhesion molecule
• ID: MGI:1916774

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	ISO	J:164563
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	IBA	J:265628
Cellular Component	GO:0005912	adherens junction	IBA	J:265628
Cellular Component	GO:0005912	adherens junction	IDA	J:69277
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:76346
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:69277
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0070830	bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	TAS	J:76346
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:164563
Biological Process	GO:0098609	cell-cell adhesion	IDA	J:69277
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IBA	J:265628
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IDA	J:76346
Biological Process	GO:0008104	protein localization	ISO	J:164563
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0030833	regulation of actin filament polymerization	ISO	J:164563