GO Annotations Graph

• Symbol: Dapk1
• Name: death associated protein kinase 1
• ID: MGI:1916885

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IDA	J:72366
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IDA	J:72366
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:161179
Molecular Function	GO:0005515	protein binding	IPI	J:157643
Molecular Function	GO:0004672	protein kinase activity	ISO	J:73065
Molecular Function	GO:0004672	protein kinase activity	IDA	J:157643
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0017075	syntaxin-1 binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:92102
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-418853
Cellular Component	GO:1990722	DAPK1-calmodulin complex	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:161179
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:161179
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:161179
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:161179
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:161179
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	IDA	J:161179
Cellular Component	GO:0014069	postsynaptic density	IDA	J:161179
Cellular Component	GO:0014069	postsynaptic density	IPI	J:161179
Cellular Component	GO:0014069	postsynaptic density	IDA	J:161179
Cellular Component	GO:0014069	postsynaptic density	IPI	J:161179
Biological Process	GO:0006915	apoptotic process	ISO	J:73065
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0071447	cellular response to hydroperoxide	ISO	J:164563
Biological Process	GO:0071346	cellular response to type II interferon	IMP	J:192858
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:164563
Biological Process	GO:0002357	defense response to tumor cell	ISO	J:164563
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:92102
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:157643
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:72366
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:72366
Biological Process	GO:0017148	negative regulation of translation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:1904094	positive regulation of autophagic cell death	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:72366
Biological Process	GO:2000310	regulation of NMDA receptor activity	IMP	J:161179
Biological Process	GO:0002834	regulation of response to tumor cell	ISO	J:164563
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0007165	signal transduction	IEA	J:72247