GO Annotations Graph

• Symbol: Exosc8
• Name: exosome component 8
• ID: MGI:1916889

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:187422
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Cellular Component	GO:0005694	chromosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0000177	cytoplasmic exosome (RNase complex)	NAS	J:320264
Cellular Component	GO:0000177	cytoplasmic exosome (RNase complex)	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0000178	exosome (RNase complex)	NAS	J:320264
Cellular Component	GO:0000178	exosome (RNase complex)	ISO	J:164563
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0000176	nuclear exosome (RNase complex)	NAS	J:320264
Cellular Component	GO:0000176	nuclear exosome (RNase complex)	IBA	J:265628
Cellular Component	GO:0101019	nucleolar exosome (RNase complex)	NAS	J:320264
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0043928	exonucleolytic catabolism of deadenylated mRNA	IBA	J:265628
Biological Process	GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA	J:265628
Biological Process	GO:0071028	nuclear mRNA surveillance	IBA	J:265628
Biological Process	GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	IBA	J:265628
Biological Process	GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	IBA	J:265628
Biological Process	GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	IBA	J:265628
Biological Process	GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	IBA	J:265628
Biological Process	GO:0006401	RNA catabolic process	ISO	J:164563
Biological Process	GO:0006396	RNA processing	ISO	J:164563
Biological Process	GO:0006364	rRNA processing	IEA	J:60000
Biological Process	GO:0034473	U1 snRNA 3'-end processing	IBA	J:265628
Biological Process	GO:0034475	U4 snRNA 3'-end processing	IBA	J:265628
Biological Process	GO:0034476	U5 snRNA 3'-end processing	IBA	J:265628