GO Annotations Graph

• Symbol: Wnk4
• Name: WNK lysine deficient protein kinase 4
• ID: MGI:1917097

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0019869	chloride channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0031404	chloride ion binding	IMP	J:274218
Molecular Function	GO:0008200	ion channel inhibitor activity	IDA	J:114139
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019870	potassium channel inhibitor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:206448
Molecular Function	GO:0005515	protein binding	IPI	J:248255
Molecular Function	GO:0005515	protein binding	IPI	J:245294
Molecular Function	GO:0005515	protein binding	IPI	J:217619
Molecular Function	GO:0005515	protein binding	IPI	J:214330
Molecular Function	GO:0005515	protein binding	IPI	J:216684
Molecular Function	GO:0005515	protein binding	IPI	J:197369
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:114792
Cellular Component	GO:0044297	cell body	IMP	J:294764
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:88439
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:284008
Biological Process	GO:0032147	activation of protein kinase activity	IDA	J:240742
Biological Process	GO:0035932	aldosterone secretion	IMP	J:184790
Biological Process	GO:0055074	calcium ion homeostasis	IMP	J:293633
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IMP	J:293633
Biological Process	GO:0006821	chloride transport	IDA	J:88439
Biological Process	GO:0072156	distal tubule morphogenesis	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:181787
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:181787
Biological Process	GO:0010467	gene expression	IMP	J:181787
Biological Process	GO:0010467	gene expression	IMP	J:181787
Biological Process	GO:0010467	gene expression	IMP	J:197369
Biological Process	GO:0010467	gene expression	IMP	J:184790
Biological Process	GO:0010467	gene expression	IGI	J:251049
Biological Process	GO:0010467	gene expression	IMP	J:277020
Biological Process	GO:0010467	gene expression	IMP	J:241978
Biological Process	GO:0010467	gene expression	IMP	J:293633
Biological Process	GO:0010467	gene expression	IMP	J:206174
Biological Process	GO:0010467	gene expression	IMP	J:275898
Biological Process	GO:0006954	inflammatory response	IMP	J:293611
Biological Process	GO:0030644	intracellular chloride ion homeostasis	IMP	J:274218
Biological Process	GO:0030644	intracellular chloride ion homeostasis	TAS	J:88439
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0042116	macrophage activation	IMP	J:293611
Biological Process	GO:0050801	monoatomic ion homeostasis	ISO	J:164563
Biological Process	GO:0050801	monoatomic ion homeostasis	IBA	J:265628
Biological Process	GO:0050801	monoatomic ion homeostasis	IMP	J:197369
Biological Process	GO:0090188	negative regulation of pancreatic juice secretion	IMP	J:172037
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:274218
Biological Process	GO:0010766	negative regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0010766	negative regulation of sodium ion transport	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1903288	positive regulation of potassium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0071805	potassium ion transmembrane transport	IMP	J:275898
Biological Process	GO:0070528	protein kinase C signaling	IDA	J:240742
Biological Process	GO:0008104	protein localization	IDA	J:84760
Biological Process	GO:0008104	protein localization	IDA	J:84958
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IMP	J:294764
Biological Process	GO:0006468	protein phosphorylation	IMP	J:293611
Biological Process	GO:0006468	protein phosphorylation	IGI	J:251049
Biological Process	GO:0006468	protein phosphorylation	IMP	J:241978
Biological Process	GO:0006468	protein phosphorylation	IMP	J:181787
Biological Process	GO:0006468	protein phosphorylation	IMP	J:211079
Biological Process	GO:0045859	regulation of protein kinase activity	IMP	J:267084
Biological Process	GO:0070294	renal sodium ion absorption	ISO	J:164563
Biological Process	GO:0003096	renal sodium ion transport	IDA	J:114139
Biological Process	GO:0002021	response to dietary excess	IMP	J:211079
Biological Process	GO:0002021	response to dietary excess	IMP	J:184790
Biological Process	GO:0002021	response to dietary excess	IMP	J:277020
Biological Process	GO:0009410	response to xenobiotic stimulus	IGI	J:207559
Biological Process	GO:0007165	signal transduction	IMP	J:182953
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:294764
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:241978
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:275898
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:284008