GO Annotations Graph

• Symbol: Spink2
• Name: serine peptidase inhibitor, Kazal type 2
• ID: MGI:1917232

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:285722
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IEA	J:72247
Cellular Component	GO:0001669	acrosomal vesicle	IDA	J:255306
Cellular Component	GO:0001669	acrosomal vesicle	ISO	J:164563
Cellular Component	GO:0001669	acrosomal vesicle	IDA	J:175913
Cellular Component	GO:0001669	acrosomal vesicle	IDA	J:285722
Cellular Component	GO:0005737	cytoplasm	IDA	J:175913
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	IDA	J:215026
Biological Process	GO:0001675	acrosome assembly	IMP	J:255306
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0009566	fertilization	IMP	J:175913
Biological Process	GO:0002176	male germ cell proliferation	IMP	J:175913
Biological Process	GO:0008584	male gonad development	IMP	J:175913
Biological Process	GO:0010466	negative regulation of peptidase activity	IEA	J:60000
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	IBA	J:265628
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	IDA	J:175913
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:215026
Biological Process	GO:0072520	seminiferous tubule development	IMP	J:175913
Biological Process	GO:0007286	spermatid development	IMP	J:255306
Biological Process	GO:0007286	spermatid development	ISO	J:164563
Biological Process	GO:0007286	spermatid development	IMP	J:175913
Biological Process	GO:0007283	spermatogenesis	IMP	J:175913