GO Annotations Graph

• Symbol: Hdac8
• Name: histone deacetylase 8
• ID: MGI:1917565

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0019213	deacetylase activity	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	TAS	J:113927
Molecular Function	GO:0004407	histone deacetylase activity	TAS	J:113927
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0004407	histone deacetylase activity	IBA	J:265628
Molecular Function	GO:0160009	histone decrotonylase activity	ISO	J:164563
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	TAS	J:113927
Cellular Component	GO:0000118	histone deacetylase complex	TAS	J:113927
Cellular Component	GO:0005634	nucleus	TAS	J:113927
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:1904322	cellular response to forskolin	ISO	J:155856
Biological Process	GO:0035984	cellular response to trichostatin A	ISO	J:155856
Biological Process	GO:0006325	chromatin organization	TAS	J:113927
Biological Process	GO:0016575	histone deacetylation	IBA	J:265628
Biological Process	GO:0007064	mitotic sister chromatid cohesion	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:2000616	negative regulation of histone H3-K9 acetylation	ISO	J:155856
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0032204	regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:1903496	response to 11-deoxycorticosterone	ISO	J:155856