GO Annotations Graph

• Symbol: Rapgef4
• Name: Rap guanine nucleotide exchange factor (GEF) 4
• ID: MGI:1917723

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030552	cAMP binding	ISO	J:155856
Molecular Function	GO:0030552	cAMP binding	IDA	J:155189
Molecular Function	GO:0005096	GTPase activator activity	IDA	J:155189
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:155856
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:155189
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:71886
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:71886
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:155189
Molecular Function	GO:0005515	protein binding	IPI	J:245330
Molecular Function	GO:0005515	protein binding	IPI	J:116396
Molecular Function	GO:0005515	protein binding	IPI	J:81000
Molecular Function	GO:0005515	protein binding	IPI	J:81000
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IDA	J:71886
Molecular Function	GO:0031267	small GTPase binding	IPI	J:155189
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005903	brush border	ISO	J:155856
Cellular Component	GO:0005929	cilium	ISO	J:155856
Cellular Component	GO:0044316	cone cell pedicle	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:71886
Cellular Component	GO:0005829	cytosol	IDA	J:71886
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0060076	excitatory synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:221665
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IMP	J:221665
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0001917	photoreceptor inner segment	ISO	J:155856
Cellular Component	GO:0001750	photoreceptor outer segment	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:73176
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:81000
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:73176
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA	J:71886
Biological Process	GO:0017156	calcium-ion regulated exocytosis	IDA	J:71886
Biological Process	GO:0006887	exocytosis	IEA	J:60000
Biological Process	GO:0046879	hormone secretion	IMP	J:198358
Biological Process	GO:0030073	insulin secretion	IDA	J:73176
Biological Process	GO:0030073	insulin secretion	IDA	J:81000
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0050805	negative regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:73176
Biological Process	GO:1904457	positive regulation of neuronal action potential	ISO	J:155856
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0050773	regulation of dendrite development	ISO	J:155856
Biological Process	GO:0017157	regulation of exocytosis	IDA	J:81000
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO	J:155856
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IMP	J:221665
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IDA	J:221665
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247