P2ry12 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

P2ry12
purinergic receptor P2Y, G-protein coupled 12
MGI:1918089

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IMP	J:70017
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	ISO	J:164563
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	ISO	J:155856
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	IMP	J:70017
Molecular Function	GO:0045028	G protein-coupled purinergic nucleotide receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0044298	cell body membrane	IGI	J:236506
Cellular Component	GO:0031253	cell projection membrane	IGI	J:236506
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:116110
Cellular Component	GO:0005886	plasma membrane	IC	J:70017
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP	J:70017
Biological Process	GO:0007596	blood coagulation	IEA	J:60000
Biological Process	GO:0007596	blood coagulation	IEA	J:72247
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:155856
Biological Process	GO:0035585	calcium-mediated signaling using extracellular calcium source	ISO	J:155856
Biological Process	GO:0030030	cell projection organization	ISO	J:155856
Biological Process	GO:0071318	cellular response to ATP	ISO	J:155856
Biological Process	GO:0071318	cellular response to ATP	IMP	J:116110
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:194901
Biological Process	GO:0021808	cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:118491
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:118491
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	IMP	J:70017
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IMP	J:70017
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008347	glial cell migration	ISO	J:155856
Biological Process	GO:0007599	hemostasis	IEA	J:60000
Biological Process	GO:0030032	lamellipodium assembly	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0045596	negative regulation of cell differentiation	ISO	J:155856
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0030168	platelet activation	IMP	J:70017
Biological Process	GO:0070527	platelet aggregation	ISO	J:164563
Biological Process	GO:0070527	platelet aggregation	ISO	J:155856
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO	J:155856
Biological Process	GO:0050921	positive regulation of chemotaxis	ISO	J:155856
Biological Process	GO:0033626	positive regulation of integrin activation by cell surface receptor linked signal transduction	ISO	J:155856
Biological Process	GO:1904141	positive regulation of microglial cell migration	ISO	J:155856
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	IGI	J:118491
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	IGI	J:118491
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:1900029	positive regulation of ruffle assembly	ISO	J:155856
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:155856
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0050920	regulation of chemotaxis	ISO	J:155856
Biological Process	GO:1904139	regulation of microglial cell migration	IDA	J:116110
Biological Process	GO:0048678	response to axon injury	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	IMP	J:116110
Biological Process	GO:0150063	visual system development	IGI	J:236506

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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