GO Annotations Graph

• Symbol: Usp19
• Name: ubiquitin specific peptidase 19
• ID: MGI:1918722

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IMP	J:182369
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:1990380	K48-linked deubiquitinase activity	IDA	J:217561
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:213961
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:217561
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:144748
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:1901799	negative regulation of proteasomal protein catabolic process	IDA	J:217561
Biological Process	GO:0048642	negative regulation of skeletal muscle tissue development	IMP	J:182369
Biological Process	GO:0090068	positive regulation of cell cycle process	ISO	J:155856
Biological Process	GO:0016579	protein deubiquitination	ISO	J:164563
Biological Process	GO:0016579	protein deubiquitination	ISO	J:155856
Biological Process	GO:0071108	protein K48-linked deubiquitination	IDA	J:217561
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IDA	J:217561
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:1900037	regulation of cellular response to hypoxia	ISO	J:164563
Biological Process	GO:1904292	regulation of ERAD pathway	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	ISO	J:155856
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	ISO	J:164563
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	J:72247