GO Annotations Graph

• Symbol: Tmprss6
• Name: transmembrane serine protease 6
• ID: MGI:1919003

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:79360
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:84865
Cellular Component	GO:0005886	plasma membrane	ISO	J:79360
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:182123
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:182123
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:182123
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:182123
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:222266
Biological Process	GO:0033619	membrane protein proteolysis	ISO	J:164563
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	ISO	J:164563
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:182123
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IGI	J:182123
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IGI	J:182123
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IGI	J:182123
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IGI	J:182123
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:222266
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:222266
Biological Process	GO:0006508	proteolysis	ISO	J:79360
Biological Process	GO:0097264	self proteolysis	ISO	J:164563