GO Annotations Graph

• Symbol: Nanog
• Name: Nanog homeobox
• ID: MGI:1919200

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:138113
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:198818
Molecular Function	GO:0003677	DNA binding	IDA	J:83420
Molecular Function	GO:0003677	DNA binding	IDA	J:107560
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:240273
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:190108
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	J:190108
Molecular Function	GO:0042802	identical protein binding	IPI	J:134614
Molecular Function	GO:0070577	lysine-acetylated histone binding	IDA	J:198818
Molecular Function	GO:0005515	protein binding	IPI	J:170271
Molecular Function	GO:0005515	protein binding	IPI	J:154829
Molecular Function	GO:0005515	protein binding	IPI	J:154829
Molecular Function	GO:0005515	protein binding	IPI	J:204621
Molecular Function	GO:0005515	protein binding	IPI	J:170278
Molecular Function	GO:0005515	protein binding	IPI	J:190108
Molecular Function	GO:0005515	protein binding	IPI	J:240581
Molecular Function	GO:0005515	protein binding	IPI	J:190201
Molecular Function	GO:0005515	protein binding	IPI	J:162391
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:170278
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0001010	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	IDA	J:240260
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:168652
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:136286
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:156932
Molecular Function	GO:0008134	transcription factor binding	IPI	J:240273
Cellular Component	GO:0000785	chromatin	IDA	J:198818
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	IDA	J:170271
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:168652
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:319899
Cellular Component	GO:0005634	nucleus	IDA	J:198818
Cellular Component	GO:0005634	nucleus	IDA	J:95814
Cellular Component	GO:0005634	nucleus	IDA	J:98502
Cellular Component	GO:0005634	nucleus	IDA	J:98502
Cellular Component	GO:0005634	nucleus	IDA	J:95814
Cellular Component	GO:0005634	nucleus	IDA	J:170416
Cellular Component	GO:0005634	nucleus	IDA	J:102832
Cellular Component	GO:0005634	nucleus	IDA	J:95814
Cellular Component	GO:0005634	nucleus	IDA	J:222297
Cellular Component	GO:0005634	nucleus	IDA	J:199456
Cellular Component	GO:0005634	nucleus	IDA	J:137356
Cellular Component	GO:0005634	nucleus	IDA	J:156932
Cellular Component	GO:0005634	nucleus	IDA	J:206154
Cellular Component	GO:0005634	nucleus	IDA	J:137356
Cellular Component	GO:0005634	nucleus	IDA	J:203796
Cellular Component	GO:0005634	nucleus	IDA	J:223575
Cellular Component	GO:0005634	nucleus	IDA	J:134633
Cellular Component	GO:0005634	nucleus	IDA	J:95814
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:111703
Biological Process	GO:0043697	cell dedifferentiation	IDA	J:240260
Biological Process	GO:0009790	embryo development	IMP	J:83420
Biological Process	GO:0009880	embryonic pattern specification	IEP	J:90050
Biological Process	GO:0001714	endodermal cell fate specification	ISO	J:168146
Biological Process	GO:0010467	gene expression	IMP	J:290525
Biological Process	GO:0010467	gene expression	IMP	J:124021
Biological Process	GO:0008406	gonad development	IEP	J:90050
Biological Process	GO:0001710	mesodermal cell fate commitment	IGI	J:111703
Biological Process	GO:0001710	mesodermal cell fate commitment	IGI	J:111703
Biological Process	GO:0001710	mesodermal cell fate commitment	IDA	J:111703
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IDA	J:111703
Biological Process	GO:0010454	negative regulation of cell fate commitment	IGI	J:111703
Biological Process	GO:0010454	negative regulation of cell fate commitment	IDA	J:111703
Biological Process	GO:0042664	negative regulation of endodermal cell fate specification	TAS	J:114820
Biological Process	GO:2000737	negative regulation of stem cell differentiation	IDA	J:127789
Biological Process	GO:2000737	negative regulation of stem cell differentiation	IDA	J:127789
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:111703
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:111703
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:182976
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:102832
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:240273
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:168652
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	IDA	J:102832
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:168652
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:168146
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:2000035	regulation of stem cell division	IDA	J:240260
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0010033	response to organic substance	IDA	J:136286
Biological Process	GO:0032526	response to retinoic acid	IDA	J:136286
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:83420
Biological Process	GO:0035019	somatic stem cell population maintenance	IDA	J:111703
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:111554
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:164442
Biological Process	GO:0048863	stem cell differentiation	IDA	J:127789
Biological Process	GO:0048863	stem cell differentiation	IDA	J:156932
Biological Process	GO:0048863	stem cell differentiation	IMP	J:114674
Biological Process	GO:0048863	stem cell differentiation	IDA	J:127789
Biological Process	GO:0017145	stem cell division	IDA	J:83680
Biological Process	GO:0019827	stem cell population maintenance	IEP	J:90050
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:242442
Biological Process	GO:0019827	stem cell population maintenance	IGI	J:125698