GO Annotations Graph

• Symbol: Ercc8
• Name: excision repaiross-complementing rodent repair deficiency, complementation group 8
• ID: MGI:1919241

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:160776
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0016363	nuclear matrix	ISO	J:73065
Cellular Component	GO:0000109	nucleotide-excision repair complex	IBA	J:265628
Cellular Component	GO:0000109	nucleotide-excision repair complex	ISO	J:73065
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0097680	double-strand break repair via classical nonhomologous end joining	ISO	J:164563
Biological Process	GO:0045739	positive regulation of DNA repair	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IBA	J:265628
Biological Process	GO:0090262	regulation of transcription-coupled nucleotide-excision repair	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0009411	response to UV	ISO	J:164563
Biological Process	GO:0009411	response to UV	ISO	J:164563
Biological Process	GO:0009411	response to UV	IMP	J:92778
Biological Process	GO:0010165	response to X-ray	IMP	J:118275
Biological Process	GO:0000012	single strand break repair	ISO	J:164563
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	IBA	J:265628
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	ISO	J:73065