GO Annotations Graph

• Symbol: Aplf
• Name: aprataxin and PNKP like factor
• ID: MGI:1919353

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	ISO	J:164563
Molecular Function	GO:0160002	ADP-D-ribose modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0004520	DNA endonuclease activity	ISO	J:164563
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	ISO	J:164563
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA	J:265628
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0140713	histone chaperone activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	ISO	J:164563
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	ISO	J:164563
Molecular Function	GO:0044183	protein folding chaperone	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:311886
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:311886
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0090734	site of DNA damage	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	IBA	J:265628
Cellular Component	GO:0035861	site of double-strand break	ISO	J:73065
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IBA	J:265628
Biological Process	GO:0006302	double-strand break repair	IMP	J:168260
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0007566	embryo implantation	IMP	J:311886
Biological Process	GO:0051106	positive regulation of DNA ligation	ISO	J:73065
Biological Process	GO:0071168	protein localization to chromatin	ISO	J:164563
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	IMP	J:311886
Biological Process	GO:0045191	regulation of isotype switching	IMP	J:168260
Biological Process	GO:0000012	single strand break repair	ISO	J:164563