GO Annotations Graph

• Symbol: Topbp1
• Name: topoisomerase (DNA) II binding protein 1
• ID: MGI:1920018

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0070532	BRCA1-B complex	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IDA	J:183982
Cellular Component	GO:0005694	chromosome	ISO	J:164563
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:90049
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:123677
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	NAS	J:320080
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0016605	PML body	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	NAS	J:320080
Biological Process	GO:0006270	DNA replication initiation	IBA	J:265628
Biological Process	GO:0035825	homologous recombination	NAS	J:320080
Biological Process	GO:0033314	mitotic DNA replication checkpoint signaling	IBA	J:265628
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	IBA	J:265628
Biological Process	GO:0007131	reciprocal meiotic recombination	ISA	J:90049
Biological Process	GO:0010212	response to ionizing radiation	ISO	J:164563