GO Annotations Graph

• Symbol: Lima1
• Name: LIM domain and actin binding 1
• ID: MGI:1920992

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IMP	J:129042
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0003785	actin monomer binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:248258
Molecular Function	GO:0005515	protein binding	IPI	J:263730
Molecular Function	GO:0005515	protein binding	IPI	J:214070
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:67542
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0031526	brush border membrane	IDA	J:263730
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0032154	cleavage furrow	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0001726	ruffle	IDA	J:129042
Cellular Component	GO:0001725	stress fiber	ISO	J:164563
Biological Process	GO:0051017	actin filament bundle assembly	ISO	J:164563
Biological Process	GO:0051017	actin filament bundle assembly	IBA	J:265628
Biological Process	GO:0016477	cell migration	IMP	J:129042
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:263730
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0030299	intestinal cholesterol absorption	IMP	J:263730
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	ISO	J:164563
Biological Process	GO:0031529	ruffle organization	IMP	J:129042
Biological Process	GO:0031529	ruffle organization	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000