GO Annotations Graph

• Symbol: Irak3
• Name: interleukin-1 receptor-associated kinase 3
• ID: MGI:1921164

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IDA	J:77382
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:77382
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:206904
Molecular Function	GO:0005515	protein binding	IPI	J:304047
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:77382
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:77382
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:304047
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:148060
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:148060
Cellular Component	GO:0005634	nucleus	IDA	J:304047
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	RCA	J:84168
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:77382
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IDA	J:77382
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IEA	J:72247
Biological Process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	IC	J:78189
Biological Process	GO:0045824	negative regulation of innate immune response	IMP	J:78189
Biological Process	GO:0032695	negative regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:78189
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IBA	J:265628
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:78189
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IMP	J:78189
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IMP	J:148060
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0042177	negative regulation of protein catabolic process	IMP	J:148060
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0043242	negative regulation of protein-containing complex disassembly	ISO	J:164563
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	IMP	J:78189
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:78189
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IBA	J:265628
Biological Process	GO:0001819	positive regulation of cytokine production	IMP	J:304047
Biological Process	GO:0010933	positive regulation of macrophage tolerance induction	IMP	J:78189
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:77382
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:77382
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:77382
Biological Process	GO:0042981	regulation of apoptotic process	RCA	J:84168
Biological Process	GO:0043244	regulation of protein-containing complex disassembly	IDA	J:77382
Biological Process	GO:0043330	response to exogenous dsRNA	IMP	J:78189
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:78189
Biological Process	GO:0032494	response to peptidoglycan	IMP	J:78189
Biological Process	GO:0009615	response to virus	IC	J:78189
Biological Process	GO:0007165	signal transduction	IEA	J:72247