GO Annotations Graph

• Symbol: Als2
• Name: alsin Rho guanine nucleotide exchange factor
• ID: MGI:1921268

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:73065
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:73065
Molecular Function	GO:0005515	protein binding	IPI	J:114917
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IBA	J:265628
Molecular Function	GO:0031267	small GTPase binding	ISO	J:73065
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005813	centrosome	IBA	J:265628
Cellular Component	GO:0005813	centrosome	ISO	J:73065
Cellular Component	GO:0005813	centrosome	IDA	J:100945
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:100945
Cellular Component	GO:0005829	cytosol	ISO	J:73065
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	IDA	J:114917
Cellular Component	GO:0005769	early endosome	ISO	J:73065
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0030027	lamellipodium	IDA	J:125624
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0014069	postsynaptic density	IDA	J:114917
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0001726	ruffle	IDA	J:125624
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Biological Process	GO:0007409	axonogenesis	ISO	J:155856
Biological Process	GO:0001662	behavioral fear response	IMP	J:100336
Biological Process	GO:0008219	cell death	ISO	J:155856
Biological Process	GO:0016197	endosomal transport	IBA	J:265628
Biological Process	GO:0016197	endosomal transport	IMP	J:104446
Biological Process	GO:0016197	endosomal transport	IMP	J:111035
Biological Process	GO:0016197	endosomal transport	IMP	J:111035
Biological Process	GO:0007032	endosome organization	ISO	J:73065
Biological Process	GO:0007626	locomotory behavior	IMP	J:100336
Biological Process	GO:0007626	locomotory behavior	IMP	J:111035
Biological Process	GO:0007041	lysosomal transport	ISO	J:73065
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:104446
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	ISO	J:73065
Biological Process	GO:0008104	protein localization	IMP	J:114917
Biological Process	GO:0008104	protein localization	IMP	J:114917
Biological Process	GO:0016601	Rac protein signal transduction	ISO	J:155856
Biological Process	GO:0001881	receptor recycling	IMP	J:114917
Biological Process	GO:0043087	regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0043087	regulation of GTPase activity	IDA	J:100945
Biological Process	GO:0006979	response to oxidative stress	IMP	J:100336
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IMP	J:114917
Biological Process	GO:0016050	vesicle organization	IDA	J:100945