GO Annotations Graph

• Symbol: Plce1
• Name: phospholipase C, epsilon 1
• ID: MGI:1921305

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IEA	J:60000
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:155856
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:164563
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IBA	J:265628
Molecular Function	GO:0004629	phospholipase C activity	ISO	J:164563
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:197247
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0006651	diacylglycerol biosynthetic process	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0032835	glomerulus development	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IBA	J:265628
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	ISO	J:155856
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045859	regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0046578	regulation of Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247