GO Annotations Graph

• Symbol: Cyld
• Name: CYLD lysine 63 deubiquitinase
• ID: MGI:1921506

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:244164
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:1990380	K48-linked deubiquitinase activity	IDA	J:112392
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	IDA	J:306372
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	IDA	J:262344
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	IBA	J:265628
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	IDA	J:112392
Molecular Function	GO:0061815	Met1-linked polyubiquitin deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0070064	proline-rich region binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:163064
Molecular Function	GO:0005515	protein binding	IPI	J:179005
Molecular Function	GO:0005515	protein binding	IPI	J:163064
Molecular Function	GO:0005515	protein binding	IPI	J:163064
Molecular Function	GO:0005515	protein binding	IPI	J:108769
Molecular Function	GO:0005515	protein binding	IPI	J:112392
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0036064	ciliary basal body	IDA	J:215909
Cellular Component	GO:0097542	ciliary tip	IDA	J:215909
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005881	cytoplasmic microtubule	ISO	J:164563
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	IEA	J:60000
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005819	spindle	ISO	J:164563
Biological Process	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IMP	J:112392
Biological Process	GO:0048872	homeostasis of number of cells	IMP	J:112392
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0070266	necroptotic process	IBA	J:265628
Biological Process	GO:0070266	necroptotic process	IMP	J:238931
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:182381
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:306372
Biological Process	GO:2000493	negative regulation of interleukin-18-mediated signaling pathway	IMP	J:306372
Biological Process	GO:0046329	negative regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0046329	negative regulation of JNK cascade	IDA	J:262344
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	IDA	J:262344
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:1903829	positive regulation of protein localization	IDA	J:112392
Biological Process	GO:0045582	positive regulation of T cell differentiation	IMP	J:112392
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	IMP	J:112392
Biological Process	GO:0016579	protein deubiquitination	IDA	J:262344
Biological Process	GO:0016579	protein deubiquitination	ISO	J:164563
Biological Process	GO:0016579	protein deubiquitination	IMP	J:180684
Biological Process	GO:0070536	protein K63-linked deubiquitination	IDA	J:262344
Biological Process	GO:0070536	protein K63-linked deubiquitination	IBA	J:265628
Biological Process	GO:1990108	protein linear deubiquitination	IDA	J:244164
Biological Process	GO:1990108	protein linear deubiquitination	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0045577	regulation of B cell differentiation	IMP	J:112392
Biological Process	GO:1902017	regulation of cilium assembly	IMP	J:215909
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:164563
Biological Process	GO:2001242	regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001242	regulation of intrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0007346	regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0007346	regulation of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0060544	regulation of necroptotic process	IDA	J:244164
Biological Process	GO:0060544	regulation of necroptotic process	ISO	J:164563
Biological Process	GO:0043393	regulation of protein binding	IDA	J:112392
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway	ISO	J:230444
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IDA	J:244164
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:1901026	ripoptosome assembly involved in necroptotic process	IMP	J:180684
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	J:72247
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000