GO Annotations Graph

• Symbol: Mlkl
• Name: mixed lineage kinase domain-like
• ID: MGI:1921818

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IDA	J:204620
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:201938
Molecular Function	GO:0005515	protein binding	IPI	J:289088
Molecular Function	GO:0005515	protein binding	IPI	J:235313
Molecular Function	GO:0005515	protein binding	IPI	J:235313
Molecular Function	GO:0019901	protein kinase binding	IPI	J:204620
Molecular Function	GO:0019901	protein kinase binding	IPI	J:204592
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:289452
Cellular Component	GO:0005737	cytoplasm	IDA	J:289082
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IDA	J:289082
Cellular Component	GO:0005634	nucleus	IDA	J:289452
Cellular Component	GO:0005886	plasma membrane	IDA	J:289082
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0051607	defense response to virus	IDA	J:289452
Biological Process	GO:0051607	defense response to virus	IMP	J:289088
Biological Process	GO:0051607	defense response to virus	IDA	J:289082
Biological Process	GO:0097528	execution phase of necroptosis	IDA	J:289452
Biological Process	GO:0097528	execution phase of necroptosis	IDA	J:289082
Biological Process	GO:0097528	execution phase of necroptosis	IMP	J:289088
Biological Process	GO:0070266	necroptotic process	IMP	J:204622
Biological Process	GO:0070266	necroptotic process	IMP	J:204620
Biological Process	GO:0070266	necroptotic process	ISO	J:164563
Biological Process	GO:0097527	necroptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097527	necroptotic signaling pathway	IMP	J:201938
Biological Process	GO:0012501	programmed cell death	IEA	J:60000
Biological Process	GO:0070207	protein homotrimerization	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247