GO Annotations Graph

• Symbol: Usp50
• Name: ubiquitin specific peptidase 50
• ID: MGI:1922333

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:240614
Molecular Function	GO:0019783	ubiquitin-like protein peptidase activity	ISO	J:240614
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0031313	extrinsic component of endosome membrane	IBA	J:265628
Cellular Component	GO:0019897	extrinsic component of plasma membrane	IBA	J:265628
Cellular Component	GO:0030496	midbody	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Biological Process	GO:0007032	endosome organization	IBA	J:265628
Biological Process	GO:0035063	nuclear speck organization	ISO	J:240614
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	ISO	J:240614
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	IMP	J:240614
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:240614
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:240614
Biological Process	GO:0032741	positive regulation of interleukin-18 production	IMP	J:240614
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:240614
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IMP	J:240614
Biological Process	GO:0016579	protein deubiquitination	ISO	J:240614
Biological Process	GO:0071108	protein K48-linked deubiquitination	IBA	J:265628
Biological Process	GO:0070536	protein K63-linked deubiquitination	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	J:72247