GO Annotations Graph

• Symbol: Sirt4
• Name: sirtuin 4
• ID: MGI:1922637

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016757	glycosyltransferase activity	IEA	J:60000
Molecular Function	GO:0004407	histone deacetylase activity	IBA	J:265628
Molecular Function	GO:0061690	lipoamidase activity	IMP	J:219204
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051287	NAD binding	IEA	J:72247
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	IMP	J:198927
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	ISO	J:129427
Molecular Function	GO:0070403	NAD+ binding	IEA	J:72247
Molecular Function	GO:0106420	NAD-dependent protein biotinidase activity	ISO	J:164563
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:199252
Molecular Function	GO:0106419	NAD-dependent protein lipoamidase activity	ISO	J:164563
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:199252
Molecular Function	GO:0005515	protein binding	IPI	J:129427
Molecular Function	GO:0033558	protein lysine deacetylase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:130436
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:199252
Cellular Component	GO:0005759	mitochondrial matrix	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:129427
Cellular Component	GO:0005739	mitochondrion	IDA	J:129009
Cellular Component	GO:0005739	mitochondrion	IDA	J:233904
Biological Process	GO:0006974	DNA damage response	IDA	J:197042
Biological Process	GO:0006541	glutamine metabolic process	IMP	J:197042
Biological Process	GO:0006541	glutamine metabolic process	IMP	J:198927
Biological Process	GO:0016575	histone deacetylation	IBA	J:265628
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	ISO	J:164563
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	IDA	J:199252
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	IMP	J:206091
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0046676	negative regulation of insulin secretion	IGI	J:129427
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:129427
Biological Process	GO:1903217	negative regulation of protein processing involved in protein targeting to mitochondrion	ISO	J:155856
Biological Process	GO:0034983	peptidyl-lysine deacetylation	IDA	J:199252
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	IDA	J:199252
Biological Process	GO:0000820	regulation of glutamine family amino acid metabolic process	IMP	J:197042
Biological Process	GO:1904182	regulation of pyruvate dehydrogenase activity	IMP	J:219204
Biological Process	GO:1904182	regulation of pyruvate dehydrogenase activity	ISO	J:164563
Biological Process	GO:0072350	tricarboxylic acid metabolic process	IMP	J:198927
Biological Process	GO:0072350	tricarboxylic acid metabolic process	IMP	J:197042