GO Annotations Graph

• Symbol: Spon2
• Name: spondin 2, extracellular matrix protein
• ID: MGI:1923724

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003823	antigen binding	IMP	J:87393
Molecular Function	GO:0003823	antigen binding	IDA	J:87393
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:87393
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:87393
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0031012	extracellular matrix	IDA	J:87393
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:87393
Biological Process	GO:0007155	cell adhesion	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:87393
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:87393
Biological Process	GO:0042742	defense response to bacterium	IMP	J:87393
Biological Process	GO:0050832	defense response to fungus	IMP	J:87393
Biological Process	GO:0051607	defense response to virus	IMP	J:87393
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0043152	induction of bacterial agglutination	IDA	J:87393
Biological Process	GO:0045087	innate immune response	IMP	J:87393
Biological Process	GO:0032635	interleukin-6 production	IDA	J:87393
Biological Process	GO:0032635	interleukin-6 production	IMP	J:87393
Biological Process	GO:0002448	mast cell mediated immunity	IMP	J:87393
Biological Process	GO:0008228	opsonization	IMP	J:87393
Biological Process	GO:0008228	opsonization	IDA	J:87393
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:87393
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:87393
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:87393
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:87393
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:87393
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:87393
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:87393
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:87393
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:87393
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:87393
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:87393
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:87393
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:87393
Biological Process	GO:0032640	tumor necrosis factor production	IDA	J:87393
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:87393