GO Annotations Graph

• Symbol: Rhbdd1
• Name: rhomboid domain containing 1
• ID: MGI:1924117

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	ISS	J:186171
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IDA	J:187613
Molecular Function	GO:0005515	protein binding	IPI	J:187613
Molecular Function	GO:0005515	protein binding	IPI	J:187613
Molecular Function	GO:0005515	protein binding	IPI	J:187613
Molecular Function	GO:0005515	protein binding	IPI	J:186060
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISS	J:186060
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:187613
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	IDA	J:187613
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0034620	cellular response to unfolded protein	IDA	J:187613
Biological Process	GO:0034620	cellular response to unfolded protein	IBA	J:265628
Biological Process	GO:0034644	cellular response to UV	IDA	J:186059
Biological Process	GO:0036503	ERAD pathway	IDA	J:187613
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	IDA	J:187613
Biological Process	GO:0033619	membrane protein proteolysis	ISO	J:164563
Biological Process	GO:0033619	membrane protein proteolysis	ISS	J:186171
Biological Process	GO:0033619	membrane protein proteolysis	ISS	J:186060
Biological Process	GO:1904211	membrane protein proteolysis involved in retrograde protein transport, ER to cytosol	IDA	J:187613
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:186059
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISS	J:186171
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISS	J:186060
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0010954	positive regulation of protein processing	IDA	J:187613
Biological Process	GO:0051047	positive regulation of secretion	ISS	J:186171
Biological Process	GO:0051047	positive regulation of secretion	ISO	J:164563
Biological Process	GO:0043687	post-translational protein modification	IDA	J:187613
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0048515	spermatid differentiation	IMP	J:186059
Biological Process	GO:0007283	spermatogenesis	IEA	J:60000