GO Annotations Graph

• Symbol: Il33
• Name: interleukin 33
• ID: MGI:1924375

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IDA	J:157197
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:249547
Molecular Function	GO:0005125	cytokine activity	IDA	J:242717
Molecular Function	GO:0005125	cytokine activity	IPI	J:124985
Molecular Function	GO:0005125	cytokine activity	IPI	J:124985
Molecular Function	GO:0002112	interleukin-33 receptor binding	IPI	J:274274
Molecular Function	GO:0005515	protein binding	IPI	J:274274
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:249547
Cellular Component	GO:0005615	extracellular space	IDA	J:242717
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:274274
Cellular Component	GO:0005634	nucleus	ISO	J:84127
Biological Process	GO:0032602	chemokine production	IDA	J:287108
Biological Process	GO:0001816	cytokine production	IDA	J:287108
Biological Process	GO:0051607	defense response to virus	IDA	J:204771
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:187651
Biological Process	GO:0010467	gene expression	IDA	J:287108
Biological Process	GO:0010467	gene expression	IDA	J:151963
Biological Process	GO:0038172	interleukin-33-mediated signaling pathway	IDA	J:287042
Biological Process	GO:0002281	macrophage activation involved in immune response	IDA	J:229370
Biological Process	GO:0030225	macrophage differentiation	IDA	J:319416
Biological Process	GO:0002282	microglial cell activation involved in immune response	IDA	J:172530
Biological Process	GO:0061518	microglial cell proliferation	IDA	J:172530
Biological Process	GO:0002638	negative regulation of immunoglobulin production	IGI	J:132106
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	IDA	J:242717
Biological Process	GO:0002686	negative regulation of leukocyte migration	IGI	J:132106
Biological Process	GO:0120042	negative regulation of macrophage proliferation	IDA	J:287042
Biological Process	GO:0002826	negative regulation of T-helper 1 type immune response	IGI	J:132106
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032689	negative regulation of type II interferon production	IGI	J:132106
Biological Process	GO:0150145	positive regulation of CD80 production	IDA	J:287042
Biological Process	GO:0150142	positive regulation of CD86 production	IDA	J:287042
Biological Process	GO:0010186	positive regulation of cellular defense response	IMP	J:287042
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IDA	J:157197
Biological Process	GO:0001819	positive regulation of cytokine production	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:287042
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:287042
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:287042
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:287042
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:287042
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:151963
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:151963
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IGI	J:132106
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:157197
Biological Process	GO:0050729	positive regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0032736	positive regulation of interleukin-13 production	IGI	J:132106
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IGI	J:132106
Biological Process	GO:0032754	positive regulation of interleukin-5 production	IGI	J:132106
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IGI	J:132106
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:287042
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:287042
Biological Process	GO:0043032	positive regulation of macrophage activation	ISO	J:164563
Biological Process	GO:0043032	positive regulation of macrophage activation	IDA	J:157197
Biological Process	GO:0043032	positive regulation of macrophage activation	IDA	J:287042
Biological Process	GO:0045345	positive regulation of MHC class I biosynthetic process	IDA	J:287042
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IDA	J:287042
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IDA	J:287042
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	J:187651
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IGI	J:187651
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IGI	J:187651
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:157197
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:287042
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:287042
Biological Process	GO:0002830	positive regulation of type 2 immune response	IGI	J:132106
Biological Process	GO:0002830	positive regulation of type 2 immune response	IDA	J:204771
Biological Process	GO:0006606	protein import into nucleus	IDA	J:287108
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IPI	J:124985
Biological Process	GO:0042092	type 2 immune response	IDA	J:204771