GO Annotations Graph

• Symbol: Akr1c21
• Name: aldo-keto reductase family 1, member C21
• ID: MGI:1924587

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	IMP	J:240451
Molecular Function	GO:0072555	17-beta-ketosteroid reductase activity	IMP	J:240451
Molecular Function	GO:0047024	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	IMP	J:240451
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IBA	J:265628
Molecular Function	GO:0004033	aldo-keto reductase (NADP) activity	ISA	J:82195
Molecular Function	GO:0047042	androsterone dehydrogenase (B-specific) activity	ISO	J:164563
Molecular Function	GO:0047023	androsterone dehydrogenase activity	IDA	J:184960
Molecular Function	GO:0047023	androsterone dehydrogenase activity	IMP	J:240451
Molecular Function	GO:0047023	androsterone dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0032052	bile acid binding	ISO	J:164563
Molecular Function	GO:0032052	bile acid binding	ISO	J:164563
Molecular Function	GO:0031406	carboxylic acid binding	ISO	J:164563
Molecular Function	GO:0031406	carboxylic acid binding	ISO	J:164563
Molecular Function	GO:0047743	chlordecone reductase activity	ISO	J:164563
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	ISO	J:164563
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	ISO	J:164563
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	IBA	J:265628
Molecular Function	GO:1902121	lithocholic acid binding	IMP	J:240451
Molecular Function	GO:0070401	NADP+ binding	IMP	J:240451
Molecular Function	GO:0070402	NADPH binding	IMP	J:240451
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO	J:164563
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO	J:164563
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO	J:164563
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity	ISO	J:164563
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity	ISO	J:164563
Molecular Function	GO:0001758	retinal dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0005496	steroid binding	IMP	J:240451
Molecular Function	GO:0016229	steroid dehydrogenase activity	IBA	J:265628
Molecular Function	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IMP	J:240451
Molecular Function	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA	J:122578
Molecular Function	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA	J:117645
Molecular Function	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006694	steroid biosynthetic process	ISA	J:82195
Biological Process	GO:0008202	steroid metabolic process	IMP	J:240451
Biological Process	GO:0008202	steroid metabolic process	IBA	J:265628