GO Annotations Graph

• Symbol: Heg1
• Name: heart development protein with EGF-like domains 1
• ID: MGI:1924696

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:229979
Molecular Function	GO:0005515	protein binding	IPI	J:146528
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0009986	cell surface	IDA	J:146528
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:146528
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:146528
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0003209	cardiac atrium morphogenesis	IGI	J:187714
Biological Process	GO:0003209	cardiac atrium morphogenesis	IMP	J:146528
Biological Process	GO:0055017	cardiac muscle tissue growth	IGI	J:187714
Biological Process	GO:0007043	cell-cell junction assembly	IEA	J:72247
Biological Process	GO:0045216	cell-cell junction organization	IMP	J:146528
Biological Process	GO:0001885	endothelial cell development	IGI	J:146528
Biological Process	GO:0001886	endothelial cell morphogenesis	IMP	J:146528
Biological Process	GO:0090269	fibroblast growth factor production	IGI	J:187714
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IGI	J:146528
Biological Process	GO:0007507	heart development	IMP	J:146528
Biological Process	GO:0001701	in utero embryonic development	IGI	J:146528
Biological Process	GO:0001701	in utero embryonic development	IMP	J:146528
Biological Process	GO:0030324	lung development	IMP	J:146528
Biological Process	GO:0003017	lymph circulation	IMP	J:146528
Biological Process	GO:0001945	lymph vessel development	IMP	J:146528
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0035264	multicellular organism growth	IGI	J:146528
Biological Process	GO:1905709	negative regulation of membrane permeability	ISO	J:164563
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:2000299	negative regulation of Rho-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0060039	pericardium development	IMP	J:146528
Biological Process	GO:0060039	pericardium development	IGI	J:146528
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	IGI	J:187714
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	IGI	J:187714
Biological Process	GO:0009791	post-embryonic development	IMP	J:146528
Biological Process	GO:1902414	protein localization to cell junction	ISO	J:164563
Biological Process	GO:0050878	regulation of body fluid levels	IMP	J:146528
Biological Process	GO:0001944	vasculature development	IGI	J:146528
Biological Process	GO:0001570	vasculogenesis	IGI	J:146528
Biological Process	GO:0048845	venous blood vessel morphogenesis	IGI	J:146528
Biological Process	GO:0003281	ventricular septum development	IMP	J:146528
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IGI	J:187714