GO Annotations Graph

• Symbol: Mthfd1l
• Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
• ID: MGI:1924836

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity	ISO	J:164563
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity	ISO	J:86417
Molecular Function	GO:0016874	ligase activity	IEA	J:60000
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:159942
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:86417
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Biological Process	GO:0009257	10-formyltetrahydrofolate biosynthetic process	ISO	J:164563
Biological Process	GO:0009257	10-formyltetrahydrofolate biosynthetic process	ISO	J:86417
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	IMP	J:193285
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	IMP	J:193285
Biological Process	GO:0006760	folic acid-containing compound metabolic process	ISO	J:164563
Biological Process	GO:0015942	formate metabolic process	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IMP	J:193285
Biological Process	GO:0006730	one-carbon metabolic process	IEA	J:60000
Biological Process	GO:0035999	tetrahydrofolate interconversion	IBA	J:265628